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Pure TMG by Manapura | The Best, Pure, Clinical-Grade Longevity & Nootropic Supplements | Free Shipping
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Pure TMG by Manapura | The Best, Pure, Clinical-Grade Longevity & Nootropic Supplements | Free Shipping
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Pure TMG by Manapura | The Best, Pure, Clinical-Grade Longevity & Nootropic Supplements | Free Shipping
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Pure TMG by Manapura | The Best, Pure, Clinical-Grade Longevity & Nootropic Supplements | Free Shipping
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Pure TMG by Manapura | The Best, Pure, Clinical-Grade Longevity & Nootropic Supplements | Free Shipping
30 Days Supply
GMP Cert.
3rd Party Tested

Pure TMG Supplement ∘ 1000mg per serving

Energy
Liver Support
Metabolism

Pure TMG to support methylation, restore deep sleep, and wake up more recovered

Great reasons to subscribe

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Accreditations

Ultra pure, high-grade ingredients only Naturally sourcedClinical-strength daily doseMicronised for maximum absorbencyLab-grade, UV safe amber glass vessel
 

TMG (trimethylglycine), also known as betaine anhydrous, is found naturally in small amounts in foods such as spinach, whole grains and shellfish. TMG is a methyl donor: it supports methylation, a process the body relies on for cell repair and for protecting cells under stress. It is commonly paired with NMN, as both play a part in the body's methylation and NAD+ pathways.

✓ Supports healthy liver function

✓ Supports heart & cardiovascular health

✓ Supports energy production & metabolism

✓ Supports deeper, more restorative sleep

✓ Supports overall cellular health

Of the observable effects, robust human results confirm that 6 weeks is an evidence-backed duration for TMG’s noticeable effects in active, resistance-training individuals.

Contains 60 capsules. One capsule contains 500mg of Pure TMG.

The capsule shell is made from 100% vegetable cellulose.

  • Vegan and Vegetarian
  • Gluten Free
  • Non-GMO
  • Allergen Free
  • Halal / Kosher Friendly

Manapura's current batch of Pure TMG has been third-party tested by an independent laboratory, and shown to be 99.62% pure.

View the certificate in our Trust Centre →

For maximum effectiveness, take two capsules daily with water.

Many people take TMG in the morning alongside NMN, as the two are often paired.

This product is intended for use by healthy adults only. Do not take if you are pregnant or breastfeeding. TMG is not suitable for individuals with a history of kidney disease.

For best results, complement your supplement routine with a balanced diet. Always consult with your doctor or healthcare professional before beginning any supplement, and never exceed the recommended daily dose.

UK ORDERS:

  • Standard Delivery (FREE):Delivered via Royal Mail 48H service.
  • Express Delivery (£3.95): Delivered via Royal Mail 24H service..

INTERNATIONAL ORDERS:

  • Standard Delivery (FREE): Delivered via Fedex Economy Services, 3-7 days.
  • Express Delivery (£3.95): Delivered via Fedex Prioirty Services, 2-4 days.

We are proud to cover customs, duties and taxes for our international customers.

Manapura delivers pure TMG capsules, clinically researched to support heart health, metabolism and liver function.

Ultra Pure

Extracted naturally - with absolutely no synthetic additives or fillers

Medical Grade

We make our supplements in certified facilities (cGMP & ISO 9001) the same standards used for best-in-class pharmaceuticals.

Micronised For Maximum Absorption

Our formulas are processed into tiny particles (micronised) so your body can absorb it more easily.

Vegan & Gluten-Free

Purposefully suitable for most diets, our zero-tolerance for additives gives you the cleanest form that the body recognises and can absorb.

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Pure TMG Supplement FAQs

What is TMG and what are its benefits?

TMG (trimethylglycine), also called betaine anhydrous, is a natural compound found in foods like beetroot and spinach. It's one of the body's key methyl donors, supporting methylation, a process involved in energy production, DNA maintenance and cellular repair. That's why it's a staple in longevity routines.

 How long do I need to supplement for to achieve the benefits?

Of the observable effects, robust human results confirm that 6 weeks is an evidence-backed duration for TMG’s noticeable effects in active, resistance-training individuals.

 When should I take TMG?

Take 2 capsules daily with water. Many people take TMG in the morning alongside NMN, as the two are often paired.

 Why take TMG with NMN?

NMN boosts NAD+, and as your body processes it, it uses up methyl groups. TMG is a rich methyl donor, so it helps keep methylation balanced. That's why longevity experts like David Sinclair pair the two.

 Can TMG enhance physical performance?

Yes, studies have shown that TMG may support endurance and muscle recovery. For this reason it pairs well with not only NMN, but also Cordyceps.

 Is TMG safe?

Yes. TMG occurs naturally in everyday foods and is well tolerated in studies at doses well above our 1,000mg daily serving.

 What's the difference between TMG and betaine HCl?

They're different supplements. TMG (betaine anhydrous) is a methyl donor that supports methylation, and it's the form paired with NMN. Betaine HCl is an acidic form taken with meals to support digestion. Manapura's TMG is pure betaine anhydrous.
What is TMG and what are its benefits?
How long do I need to supplement for to achieve the benefits?
When should I take TMG?
Why take TMG with NMN?
Can TMG enhance physical performance?
Is TMG safe?
What's the difference between TMG and betaine HCl?

Every single batch is tested by third-party labs.

Batch tested for heavy metals, toxins, and unwanted contaminants. Nothing gets shipped unless it meets the highest safety standards.

  • 5 stars: 22 (100%)
  • 4 stars: 0 (0%)
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  • 1 star: 0 (0%)
Some of the reviews shown are from related products the merchant grouped with this one.
F
Frances C.

Excellent product

Frances C. review photo
A
Anonymous

Loving the Manapura TMG alongside my usual NMN.

Anonymous review photo
L
Lucy P.

I loved the lionsmane tincture. It made a huge difference to my brain fog. It's so hard to find a genuinely pure product but this is it!!

Lucy P. review photo
a
aida

super

A
Anonymous

Cool brand !

K
Kathy W.

Best NAD product on the market!

R
Ross C.

Steady energy building up after 2 months use along with NMN. Unlike other products it works.

R
Raymond

recommended. good delivery speed, and good product

R
Richard

Lovely product, and arrived very quickly

L
Louise B.
Pure TMG

Quick delivery thank you! Trying these out as a liver supplement.

A
Andy M.
Pure TMG

I ordered the NAD Duo as my PT recommended the Manapura NMN - noticed a much better recovery after training since taking both for the last 3 weeks. It all feels very premium, will be trying more of the range.

C
Camilla B.
Pure TMG

I bought this as was looking into liver support after noticing sluggish digestion and fatigue and couldn't pin point it. I came across a few studies showing TMG's role in improving liver function and methylation, so I gave TMG a try. I've taken for 3 weeks and so far do feel way less bloated, and more balanced. It's reassuring to know this is a UK company too.

D
Dominic P.
Pure TMG

I've been taking NMN for a year and love it. I saw Dr. Huberman say to add TMG, so I gave it a try.

Now my energy feels steadier and my focus better. It's easy to take, supports heart and liver health, and I like that it comes in glass instead of plastic.

A
Andrew H.
Pure TMG

I take TMG with NMM to increase NAD+ and these products are high purity. Overall feeling much better. Also an improvement in sleep quality.

J
Jon H.
Pure TMG

Added TMG to my stack alongside NMN to boost NAD+ levels and it's made a big difference. Energy feels more balanced, and generally feel a lot better.

L
Leo T.
Pure TMG

6 weeks in and seeing recovery from gym sessions to be much better and a general mood improvement

D
Daniel G.
Pure TMG

Really fast delivery and very nicely presented.
High end product and I've noticed a positive effect since taking it, highly recommend.

S
Stephanie D.
Pure TMG

I love this product, I really noticed a difference where better recovery after my workouts and my mental clarity had improved. Would recommend!

R
Ryan V.
Pure TMG

Great product, great service. Loving being a monthly subscriber

K
Keith N.
Pure TMG

Pure TMG has really helped regulate my sleep, I'm also starting to see my fitness improving with better energy in the gym. I will definitely buy again!

S
Sam S.
Pure TMG

Excellent website, service and products

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Meet our Advisors

Dr. Cherry Lo, Ph.D., is a researcher specialising in pathology and immunity, with degrees from CUHK and the University of Hong Kong. Her work focuses on the interaction between NK cells and rheumatoid arthritis, providing new insights into disease mechanisms. As a research scientist, she contributes to advancements in longevity science. With a passion for immunology and translational research, Dr. Lo is dedicated to uncovering innovative solutions for age-related diseases and immune health.

DR. CHERRY LO, Ph.D

Longevity Expert

READ INTERVIEW

Dr. Cherry Lo, Ph.D., is a researcher specialising in pathology and immunity, with degrees from CUHK and the University of Hong Kong. Her work focuses on the interaction between NK cells and rheumatoid arthritis, providing new insights into disease mechanisms. As a research scientist, she contributes to advancements in longevity science. With a passion for immunology and translational research, Dr. Lo is dedicated to uncovering innovative solutions for age-related diseases and immune health.

DR. CHERRY LO, Ph.D

Longevity Expert

Ben is the founder and head grower at one of the UK’s leading fungi farms, where he cultivates a deep passion for mushroom cultivation and education. Since launching his farm in 2022, he has dedicated himself to exploring fungi’s medicinal and ecological potential. Ben is a regular speaker at functional mushroom conferences around the UK where he shares his knowledge and enthusiasm for the fungal kingdom. He aims to inspire others to connect with these fascinating organisms.

BEN GIBSON

Mycology Expert

Ben is the founder and head grower at one of the UK’s leading fungi farms, where he cultivates a deep passion for mushroom cultivation and education. Since launching his farm in 2022, he has dedicated himself to exploring fungi’s medicinal and ecological potential. Ben is a regular speaker at functional mushroom conferences around the UK where he shares his knowledge and enthusiasm for the fungal kingdom. He aims to inspire others to connect with these fascinating organisms.

BEN GIBSON

Mycology Expert

Carolina is a holistic sleep coach specialising in circadian biology, nutritional therapy, and biohacking. With over seven years of experience, she blends scientific research with ancestral wisdom to help clients achieve deep, restorative sleep naturally. Her expertise in light exposure, stress resilience, and nervous system regulation allows her to create personalised, sustainable solutions without reliance on medication. Carolina is passionate about empowering individuals to optimise their sleep and overall well-being through evidence-based, holistic practices.

CAROLINA RAMUSKI

Sleep Expert

Carolina is a holistic sleep coach specialising in circadian biology, nutritional therapy, and biohacking. With over seven years of experience, she blends scientific research with ancestral wisdom to help clients achieve deep, restorative sleep naturally. Her expertise in light exposure, stress resilience, and nervous system regulation allows her to create personalised, sustainable solutions without reliance on medication. Carolina is passionate about empowering individuals to optimise their sleep and overall well-being through evidence-based, holistic practices.

CAROLINA RAMUSKI

Sleep Expert